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sto 609 acetate  (Tocris)


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    Tocris sto 609 acetate
    Sto 609 Acetate, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 39 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sto 609 acetate/product/Tocris
    Average 94 stars, based on 39 article reviews
    sto 609 acetate - by Bioz Stars, 2026-02
    94/100 stars

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    camkkβ inhibitor 7 oxo 7hbenzimidazo  (Tocris)
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    LY294002 prevented the phosphorylation of AKT, mTOR, p70S6K, and 4E-BP1 induced by 0.25 mM LA in high glucose-cultured MCs. Cells were preincubated with high glucose medium for 1 h and then stimulated with different concentrations of LY294002 in the presence of 0.25 mM LA for an additional 24 h. The phosphorylation of AKT ((a) panel (A)), mTOR ((a) panel (B)), 4E-BP1 ((a) panel (C)), and p70S6K ((a) panel (D)) was determined by immunoblot analysis. STO-609 reversed the phosphorylation of AMPK, mTOR, p70S6K, and 4E-BP1 induced by 1.0 mM LA in high glucose-treated MCs. Cells were preincubated with high glucose medium for 1 h and then stimulated with various concentrations of STO-609 in the presence of 1.0 mM LA for 24 h. The phosphorylation of AMPK ((b) panel (A)), mTOR ((b) panel (B)), 4E-BP1 ((b) panel (C)), and p70S6K ((b) panel (D)) in cells was determined by immunoblot analysis. β -Actin was used as a control to ensure equal protein loading. Representative blots (left) and densitometric analyses (right) are shown. Values are given as mean ± SD; P < 0.05 was considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Journal: International Journal of Endocrinology

    Article Title: Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway

    doi: 10.1155/2014/658589

    Figure Lengend Snippet: LY294002 prevented the phosphorylation of AKT, mTOR, p70S6K, and 4E-BP1 induced by 0.25 mM LA in high glucose-cultured MCs. Cells were preincubated with high glucose medium for 1 h and then stimulated with different concentrations of LY294002 in the presence of 0.25 mM LA for an additional 24 h. The phosphorylation of AKT ((a) panel (A)), mTOR ((a) panel (B)), 4E-BP1 ((a) panel (C)), and p70S6K ((a) panel (D)) was determined by immunoblot analysis. STO-609 reversed the phosphorylation of AMPK, mTOR, p70S6K, and 4E-BP1 induced by 1.0 mM LA in high glucose-treated MCs. Cells were preincubated with high glucose medium for 1 h and then stimulated with various concentrations of STO-609 in the presence of 1.0 mM LA for 24 h. The phosphorylation of AMPK ((b) panel (A)), mTOR ((b) panel (B)), 4E-BP1 ((b) panel (C)), and p70S6K ((b) panel (D)) in cells was determined by immunoblot analysis. β -Actin was used as a control to ensure equal protein loading. Representative blots (left) and densitometric analyses (right) are shown. Values are given as mean ± SD; P < 0.05 was considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Article Snippet: The CaMKK specific inhibitor STO-609 acetic acid was purchased from Sigma-Aldrich.

    Techniques: Cell Culture, Western Blot

    MTT assay for cell proliferation analysis. LY294002 dose-dependently inhibited mesangial cell proliferation induced by 0.25 mM LA. 10 μ g/mL STO-609 completely abolished the inhibition of mesangial cell proliferation, which was caused by 1.0 mM LA. Data in the bar graphs represent the mean ± SD ( n = 6). P < 0.05 was considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Journal: International Journal of Endocrinology

    Article Title: Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway

    doi: 10.1155/2014/658589

    Figure Lengend Snippet: MTT assay for cell proliferation analysis. LY294002 dose-dependently inhibited mesangial cell proliferation induced by 0.25 mM LA. 10 μ g/mL STO-609 completely abolished the inhibition of mesangial cell proliferation, which was caused by 1.0 mM LA. Data in the bar graphs represent the mean ± SD ( n = 6). P < 0.05 was considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Article Snippet: The CaMKK specific inhibitor STO-609 acetic acid was purchased from Sigma-Aldrich.

    Techniques: MTT Assay, Inhibition

    LY294002 inhibited cell-cycle progression induced by 0.25 mM LA in high glucose-cultured MCs. STO-609 prevented the inhibition of high glucose-stimulated mesangial cell-cycle progression caused by 1.0 mM LA. MCs were pretreated with high glucose (30 mM) for 1 h and then incubated with LY294004 (0, 2.5, 5, 10 μ mol/L) plus 0.25 mM LA or STO-609 (0, 2.5, 5, 10 μ g/mL) plus 1.0 mM LA, respectively, for an additional 24 h. Cells were analyzed by flow cytometry after PI staining. Data in the bar graphs represent the mean ± SD ( n = 3). P < 0.05 was considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Journal: International Journal of Endocrinology

    Article Title: Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway

    doi: 10.1155/2014/658589

    Figure Lengend Snippet: LY294002 inhibited cell-cycle progression induced by 0.25 mM LA in high glucose-cultured MCs. STO-609 prevented the inhibition of high glucose-stimulated mesangial cell-cycle progression caused by 1.0 mM LA. MCs were pretreated with high glucose (30 mM) for 1 h and then incubated with LY294004 (0, 2.5, 5, 10 μ mol/L) plus 0.25 mM LA or STO-609 (0, 2.5, 5, 10 μ g/mL) plus 1.0 mM LA, respectively, for an additional 24 h. Cells were analyzed by flow cytometry after PI staining. Data in the bar graphs represent the mean ± SD ( n = 3). P < 0.05 was considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Article Snippet: The CaMKK specific inhibitor STO-609 acetic acid was purchased from Sigma-Aldrich.

    Techniques: Cell Culture, Inhibition, Incubation, Flow Cytometry, Staining

    LY294002 prevented the secretions of FN and collagen-I induced by 0.25 mM LA in high glucose-cultured MCs. STO-609 reversed the inhibition of FN and collagen-I secretions induced by 1.0 mM LA in high glucose-treated MCs. (a) Representative of the effects of LY294002 on 0.25 mM LA induced FN and collagen secretion in supernatants. (b) Representative of the effects of STO-609 on 1.0 mM LA induced FN and collagen secretion in supernatants. Values are given as mean ± SD from 3 independent experiments in quadruplicate and P < 0.05 is considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Journal: International Journal of Endocrinology

    Article Title: Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway

    doi: 10.1155/2014/658589

    Figure Lengend Snippet: LY294002 prevented the secretions of FN and collagen-I induced by 0.25 mM LA in high glucose-cultured MCs. STO-609 reversed the inhibition of FN and collagen-I secretions induced by 1.0 mM LA in high glucose-treated MCs. (a) Representative of the effects of LY294002 on 0.25 mM LA induced FN and collagen secretion in supernatants. (b) Representative of the effects of STO-609 on 1.0 mM LA induced FN and collagen secretion in supernatants. Values are given as mean ± SD from 3 independent experiments in quadruplicate and P < 0.05 is considered statistically significant. Note: * P < 0.05 versus NG; # P < 0.05 versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

    Article Snippet: The CaMKK specific inhibitor STO-609 acetic acid was purchased from Sigma-Aldrich.

    Techniques: Cell Culture, Inhibition